Journal article
Lam Tan Hao, Sohee Park, S. Choy, Young-Min Kim, Seung-Woo Lee, Y. Ok, J. Koo, S. Hwang, D. Hwang, Jeyoung Park, D. Oh
JACS Au, 2021
JACS Au, 2021
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APA
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Hao, L. T., Park, S., Choy, S., Kim, Y.-M., Lee, S.-W., Ok, Y., … Oh, D. (2021). Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue. JACS Au.
Chicago/Turabian
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Hao, Lam Tan, Sohee Park, S. Choy, Young-Min Kim, Seung-Woo Lee, Y. Ok, J. Koo, et al. “Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue.” JACS Au (2021).
MLA
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Hao, Lam Tan, et al. “Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue.” JACS Au, 2021.
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@article{lam2021a,
title = {Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue},
year = {2021},
journal = {JACS Au},
author = {Hao, Lam Tan and Park, Sohee and Choy, S. and Kim, Young-Min and Lee, Seung-Woo and Ok, Y. and Koo, J. and Hwang, S. and Hwang, D. and Park, Jeyoung and Oh, D.}
}
Abstract
Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation−π interactions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives.